One CD4+TCR and One CD8+TCR Targeting Autochthonous Neoantigens Are Essential and Sufficient for Tumor Eradication

To achieve eradication of solid tumors, investigators examined how many neoantigens need to be targeted with how many TCRs by which type of T cells. Unmanipulated, naturally expressed neoantigens were targeted with adoptively transferred TCR-engineered autologous T cells.