Liver ACSM3 Deficiency Mediates Metabolic Syndrome via a Lauric Acid-HNF4α-p38 MAPK Axis

Researchers explored the mechanistic basis of metabolic syndrome by recruiting an essential patient cohort and performing extensive gene expression profiling. The mitochondrial fatty acid metabolism enzyme acyl-CoA synthetase medium-chain family member 3 (ACSM3) was identified to be significantly lower expressed in the peripheral blood of metabolic syndrome patients.