p53 Suppresses Lipid Droplet-Fueled Tumorigenesis Through Phosphatidylcholine

Scientists found that the tumor suppressor p53 drives the Kennedy pathway via PCYT1B to control the growth of lipid droplets (LDs) and their fueling role in tumorigenesis. Mechanistically, through upregulation of PCYT1B, p53 channeled depleted choline stores to phosphatidylcholine biosynthesis during choline starvation, thus preventing LD coalescence.