Carbon Ion and Photon Radiotherapy Show Enhanced Anti-Tumoral Therapeutic Efficacy with Neoantigen RNA-LPX Vaccines in Preclinical Colon Carcinoma Models

Researchers investigated the potential of carbon-ion radiotherapy and isoeffective doses of X-ray radiotherapy to mediate tumor growth inhibition and survival in murine colon adenocarcinoma models in conjunction with neoantigen-specific liposome-formulated mRNA vaccines vaccines, encoding both MHC class I and II-restricted tumor-specific neoantigens.