Identification of Aberrant Luminal Progenitors and mTORC1 as a Potential Breast Cancer Prevention Target in BRCA2 Mutation Carriers

Using preneoplastic specimens from age-matched, premenopausal females, the authors showed broad dysregulation across the luminal compartment in BRCA2mut/+ tissue, including expansion of aberrant ERBB3lo luminal progenitor and mature cells, and the presence of atypical ER-positive lesions.