Cationic Hydrogels Modulate Neural Stem and Progenitor Cell Proliferation and Differentiation Behavior in Dependence of Cationic Moiety Concentration in 2D Cell Culture

Researchers developed a well-defined, fully synthetic hydrogel system that allowed for the precise control of the concentration of cationic trimethylaminoethyl acrylate molecules associated with the polymer in a range from 0.06 to 0.91 μmol/mg. When murine neural stem/progenitor cells (NSPCs) were cultured on these gels under differentiation conditions, they observed a strong correlation of cationic charge concentration with NSPC survival.