TKT-PARP1 Axis Induces Radioresistance by Promoting DNA Double-Strand Break Repair in Hepatocellular Carcinoma

Scientists investigated the functional role of transketolase (TKT) in the repair of DNA double-strand breaks (DSBs) in HCC. They unveiled that TKT was involved in DSB repair, and its depletion significantly reduces both non-homologous end joining and homologous recombination-mediated DSB repair.