DPYSL5 Is Highly Expressed in Treatment-Induced Neuroendocrine Prostate Cancer and Promotes Lineage Plasticity via EZH2/PRC2

Dihydropyrimidinase-related protein 5 (DPYSL5) overexpression in prostate cancer cells induced a neuron-like phenotype, enhanced invasion, proliferation, and upregulated stemness and neuroendocrine-related markers.