Antioxidative Hyaluronic Acid-Bilirubin Nanomedicine Targeting Activated Hepatic Stellate Cells for Anti-Hepatic-Fibrosis Therapy

Scientists developed a strategy that combines CD44-targeting of activated hepatic stellate cells (HSCs) with an antioxidative approach. They demonstrated that intravenously administered hyaluronic acid–bilirubin nanoparticles effectively targeted the liver, particularly activated HSCs, in fibrotic mice with choline-deficient l-amino acid-defined high-fat diet-induced nonalcoholic steatohepatitis.