Hepatic Stellate Cell-Targeting Micelle Nanomedicine for Early Diagnosis and Treatment of Liver Fibrosis

The authors developed a silica cross-linked micelles (SCLMs) based nano-system for both diagnosing and treating liver fibrosis. The SCLMs were firstly modified with peptide CTCE9908 and could actively target CXCR4, which was overexpressed in activated hepatic stellate cells.