Sterile Inflammation via TRPM8 RNA-Dependent TLR3-NF-kB/IRF3 Activation Promotes Antitumor Immunity in Prostate Cancer

Prostate cells secreted TRPM8 RNA into extracellular vesicles, which primed TLR3/NF-kB-mediated inflammatory signaling after extracellular vesicle endocytosis by epithelial cancer cells.