PARD3 Drives Tumorigenesis through Activating Sonic Hedgehog Signaling in Tumour-Initiating Cells in Liver Cancer

The essential role of PARD3 in mediating hepatic tumorigenesis was assessed in diet-induced spontaneous liver tumour and syngeneic tumour models. The mechanism of PARD3 was delineated by bulk and single-cell RNA sequencing.