Sex-Determining Region Y Gene Promotes Liver Fibrosis and Accounts for Sexual Dimorphism in Its Pathophysiology

Hepatocyte-specific SRY knock-in, SRY knockout, and SRY KI with platelet-derived growth factor receptor α KO mice were generated. Liver fibrosis was induced in mice by bile duct ligation for two weeks or carbon tetrachloride treatment for six weeks.