Quantitative Systems Pharmacology Modeling of HER2-Positive Metastatic Breast Cancer for Translational Efficacy Evaluation and Combination Assessment Across Therapeutic Modalities

The authors developed a mechanistic quantitative systems pharmacology model of the pathophysiology of HER2+ metastatic breast cancer that was extensively calibrated and validated against multiscale data to quantitatively predict and characterize the signal transduction and preclinical tumor growth kinetics under different therapeutic interventions.