Plasticity-Induced Repression of Irf6 Underlies Acquired Resistance to Cancer Immunotherapy in Pancreatic Ductal Adenocarcinoma

Using a mouse model of PDAC to study tumor relapse following immunotherapy-induced responses, researchers found that resistance was reproducibly associated with an epithelial-to-mesenchymal transition (EMT), with EMT-transcription factors ZEB1 and SNAIL functioning as master genetic and epigenetic regulators of this effect.