Machine Learning Links T Cell Function and Spatial Localization to Neoadjuvant Immunotherapy and Clinical Outcome in Pancreatic Cancer

Scientists designed a multiplex immunohistochemistry antibody panel to compare T cell functionality and spatial localization in resected tumors from treatment-naive patients with localized PDAC with resected tumors from a second cohort of patients treated with neoadjuvant agonistic CD40 monoclonal antibody therapy.