ASK1/p38 Axis Inhibition Blocks the Release of Mitochondrial “Danger Signals” From Hepatocytes and Suppresses Progression to Cirrhosis and Liver Cancer

Short- and long-term ASK1 inhibition using small molecule GS-444217 was tested in thioacetamide-induced and BALB/c.Mdr2-/- murine models of cirrhosis and HCC, and in vitro using primary hepatocyte cell death assays.