Dynamic and Distinct Histone Modifications Facilitate Human Trophoblast Lineage Differentiation

Through comprehensive mapping of H3K4me3, H3K27me3, H3K9me3, and H3K27ac loci during the differentiation of trophoblast stem cells into syncytiotrophoblasts and extravillous trophoblasts, the authors revealed dynamic reconfiguration in H3K4me3 and H3K27ac patterns that establish an epigenetic landscape conducive to proper trophoblast lineage differentiation.