miR615-3p Inhibited FBLN1 and Osteogenic Differentiation of Umbilical Cord Mesenchymal Stem Cells by Associated With YTHDF2 in a m6A-miRNA Interaction Manner

The authors found that FBLN1 promoted osteogenic differentiation of MSCs and MSC-mediated bone regeneration. It was showed that there was an m6A methylation site in 3′UTR of FBLN1 mRNA, and the mutation of the m6A site enhanced the stability of FBLN1 mRNA, subsequently fostering the FBLN1 enhanced osteogenic differentiation of WJCMSCs.