Hypoxia-Activated XBP1s Recruits HDAC2-EZH2 to Engage Epigenetic Suppression of ΔNp63α Expression and Promote Breast Cancer Metastasis Independent of HIF1α

Investigators discovered that hypoxia promoted breast cancer metastasis through suppression of ΔNp63α in a hypoxia-inducible factor 1 α (HIF1α)-independent manner.