Metabolic Rescue of α-Synuclein-Induced Neurodegeneration through Propionate Supplementation and Intestine-Neuron Signaling in C. elegans

Scientists found that the short-chain fatty acid propionate protected against α-synuclein-induced neuronal death and locomotion defects in a Caenorhabditis elegans model of Parkinson’s disease through bidirectional regulation between the intestine and neurons.