Progesterone Receptor Potentiates Macropinocytosis through CDC42 in Pancreatic Ductal Adenocarcinoma

The authors found that progesterone receptor (PGR), a steroid-responsive nuclear receptor, is highly expressed in PDAC tissues obtained from both patients and transgenic LSL-KrasG12D/+; LSL-Trp53R172H/+; PDX1-cre mice.