Shear Stress Activates the Piezo1 Channel to Facilitate Valvular Endothelium-Oriented Differentiation and Maturation of Human Induced Pluripotent Stem Cells

Scientists applied unidirectional shear stress to promote hiPSCs differentiation into valvular endothelial-like (VELs) cells. They found that Piezo1 served as a crucial mechanosensor for the differentiation and maturation of VELs.