Whole-Genome DNA Methylation Profiling of Intrahepatic Cholangiocarcinoma Reveals Prognostic Subtypes with Distinct Biological Drivers

Investigators conducted whole-genome bisulfite sequencing on 331 intrahepatic cholangiocarcinoma (iCCAs) integrated with genetic, transcriptomic, and proteomic analyses, demonstrating the existence of four DNA methylation subtypes of iCCAs that exhibited unique post-operative clinical outcomes.