Preclinical Evaluation of Off-The-Shelf PD-L1+ Human Natural Killer Cells Secreting IL15 to Treat Non-Small Cell Lung Cancer

Researchers investigated the safety and efficacy of tumor-reactive and cytokine-activated Natural Killer (NK) cells, human NK cells from umbilical cord blood were expanded, transduced with a retroviral vector encoding soluble IL15, and further cytokine activated to induce PD-L1 expression.