UPF1 Deficiency Enhances Mitochondrial ROS Which Promotes an Immunosuppressive Microenvironment in Pancreatic Ductal Adenocarcinoma

Upstream frameshift 1 (Upf1) helicase deficiency led to increased mitochondrial complex I activity which produced reactive oxygen species (ROS) that signaled for cytokine release that drove immune suppression and enhanced pancreatic tumor growth.