Newsletters

CD8+ T Cells Sustain Vaccination-Induced Immunity against Dissemination of Contained Tuberculosis in Immunosuppressed Hosts

[Nature Communications] Scientists showed that immunosuppression-induced dissemination of lymphatic Mycobacterium tuberculosis and ensuing progressive disease can be prevented by vaccination with BCG or recombinant BCG even in the absence of CD4+ T cells.

A New mRNA Antigen Vaccine Induces Potent B and T Cell Responses and In Vivo Protection against SARS-CoV-2

[NPJ Vaccines] Scientists added new T cell epitopes to the receptor-binding domain RBD mRNA vaccine and identified a SARS-CoV-2 membrane epitope that significantly improved vaccine-induced immunity and protection in vivo.

CD4+ T Cell-Mediated Immunity Protects from VSV-SUD Lethal Challenge in a Mouse Model of Sudan Virus Infection

[Nature Immunology] To unravel mechanisms contributing to protection, researchers used a surrogate mouse model of Sudan virus infection amenable to deep functional analysis.

Host Macrophages/Monocytes Promote Malaria Transmission by Modulating Mosquito Microbiota via SR-a-Mediated Phagocytosis

[Nature Communications] Researchers demonstrated that macrophages/monocytes—rather than neutrophils or NK/NKT cells—play a crucial role in enhancing malaria transmission to mosquitoes, both in rodent models and human.

Exposed Phosphatidylserine Is an Inhibitory Molecule in T Cell Exhaustion

[Nature] Researchers showed that viable, antigen-specific CD8 T cells externalize phosphatidylserine during lymphocytic choriomeningitis virus infection.

Tessera Therapeutics Receives Grant to Advance In Vivo Gene Writing Approaches Towards a Potential Human Immunodeficiency Virus (HIV) Cure

[Tessera Therapeutics] Tessera Therapeutics announced that it has received a grant from the Gates Foundation to support early-stage research exploring multiple genetic approaches aimed at developing a scalable cure for HIV.

Global Virus Network Awards Education & Training Grants to Advance Next-Generation Virology Research and Pandemic Preparedness

[Global Virus Network ] The Global Virus Network announced the recipients of $90,000 in 2025 Education and Training Grants, supporting emerging scientists and institutions advancing translational virology, genomic surveillance, data-driven preparedness, and global health equity.

Sirtuin2 Blockade Inhibits Replication of Human Immunodeficiency Virus-1 and Mycobacterium Tuberculosis in Macrophages and Humanized Mice

[Molecular Therapy] Researchers found that human M1 macrophages inhibit Mycobacterium tuberculosisgrowth, while M2 macrophages, characterized by elevated Sirt2 expression, permit Mtb growth

Interleukin 11-Induced MicroRNAs As Functional Mediators and Circulating Biomarkers of Cardiac Fibrosis

[Circulation Research] Researchers investigated the translational potential of IL-11–regulated microRNAs as circulating biomarkers of cardiac fibrosis in patients with aortic stenosis.

Tailored Extracellular Matrix-Biomimetic Coating Favors Tissue Healing by Modulating the Microenvironment

[ACS Nano] Scientists proposed an ECM-biomimetic microenvironment-regulating coating, where a polyethylene glycol linker with antifouling effects is used to graft tailored recombinant humanized collagen type I possessing high cell-adhesive activity via an efficient click reaction.

Inhaled Angiopoietin-Like 4 Antisense Oligonucleotide Therapy for Lung Injury and Fibrosis

[Advanced Science] Investigators showed that inhalationally delivered, lung-targeted antisense oligonucleotides against angiopoietin-like 4 attenuate both infectious and fibrotic lung disease.

The Conserved Fibroblast Growth Factor Receptor-Based Signaling Is Required for Dendrite Regeneration

[Proceedings of the National Academy of Sciences of the United States of America] Researchers uncovered that the fibroblast growth factor receptor pathway is necessary within the neuron to initiate branching from the broken dendrite tip.
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