Newsletters

[Blackstone Life Sciences] Blackstone Life Sciences announced a research and development funding agreement to advance the clinical development of bleximenib (JNJ-75276617), an investigational oral menin inhibitor, for AML.

[Nature Communications] The authors showed that newly specified hematopoietic stem and progenitor cells (HSPCs) achieve this unique state by precise spatio-temporal regulation of reactive oxygen species via Bnip3lb-associated developmentally-programmed mitophagy, a distinct autophagic regulatory mechanism from that of adult HSPCs.

[Biomaterials] Investigators presented a porous microscaffold that enables robust hematopoietic differentiation from human pluripotent stem cell-derived mesoderm.

[Leukemia] Using mouse models and primary human samples, researchers investigated the impact of SRSF2 mutations on erythropoiesis. They found reduced erythropoiesis in Srsf2^P95H versus wild-type mice upon stress-induced erythropoiesis.

[Blood Advances] To explore the regulation of erythropoiesis in the bone marrow in response to anemia, investigators studied the role of E-cadherin in the erythroid lineage of rats.

[FASEB Journal] Researchers showed that GATA1 forms dynamic nuclear condensates in HEK293T, HUDEP2 progenitors, and erythroleukemia cells, as well as concentration-dependent droplets in vitro.

[Blood] Investigators demonstrated that AML cells upregulate the peroxisomal very-long-chain fatty acid transporter ABCD1 and increase endogenous levels of peroxisomal fatty acid oxidation relative to healthy hematopoietic cells.

[Molecular Oncology] Scientists showed that approved drugs inhibiting inosine-5′-monophosphate dehydrogenase (IMPDH)—mycophenolic acid and ribavirin—imbalance deoxyribonucleoside triphosphate pools and increase ara-C efficacy in SAMHD1-proficient, but not deficient, leukaemic cells.

[Annals of Hematology] Researchers investigated the impact of adding pioglitazone to imatinib therapy in 26 newly diagnosed chronic-phase chronic myeloid leukemia patients. Results suggested that pioglitazone may enhance early molecular response and suppress leukemia stem cells-associated genes.

[Aging Cell] Scientists provide an overview of the current literature on intersections of different forms of clonal haematopoiesis (CH), the clinical implications of these, and a perspective on how CH enhances our understanding of the biology of aging.

[International Journal of Oral Science] Researchers explored a neural crest-like progenitor niche in bone marrow MSCs with high neurogenic and proliferative capacity by single-cell transcriptomics.

[ACS Nano] Scientists developed a hybrid gelled nanovesicle, Hy-gNVs@chol, through chitosan-based protein enrichment and functional membrane replacement, enabling efficient concentration of MSC components to form gel nanoparticles while conferring inflammation-targeting capability.