A Noncoding Variant Confers Pancreatic Differentiation Defect and Contributes to Diabetes Susceptibility by Recruiting RXRA

Researchers focused on a noncoding variant, rs6048205, and reported that the risk-G variant impaired the generation of PDX1+/NKX6-1+ pancreatic progenitor cells and further resulted in the abnormal decrease of functional β cells during pancreatic differentiation.