Cancer-Associated Fibroblasts Maintain Critical Pancreatic Cancer Cell Lipid Homeostasis in the Tumor Microenvironment

Researchers demonstrated that PDAC cell survival was highly dependent on unsaturated lysophosphatidylcholines secreted by cancer-associated fibroblasts due to markedly reduced Δ9 stearoyl-coenzyme A (CoA) desaturase 1 activity in tumor cells.