Proteasomal Processing of the Viral Replicase ORF1 Facilitates HEV-Induced Liver Fibrosis

By
Emily Salmini
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895
Researchers found that the viral multiple-domain replicase (ORF1) underwent unique ubiquitin–proteasomal processing leading to formation of the HEV-Derived SMAD Activator, a viral polypeptide lacking putative helicase and RNA polymerase domains.
[Proceedings of The National Academy of Sciences of The United States of America]
Abstract