Newsletters

[Nature Biomedical Engineering] Researchers reported the development of two human spinal cord organoid injury models to simulate spinal cord injury in vitro, a laceration of the organoid with a scalpel and a compressive contusion commonly used in preclinical models, both resulting in immediate neuronal death and the formation of glial scar-like tissue.

[Advanced Healthcare Materials] Scientists developed 3D cardiac organoids from Duchenne muscular dystrophy patient-derived iPSCs, their isogenic control, and a healthy hiPSC line.

[JCI Insight] Investigators developed a framework combining the use of patient-derived cells and kidney organoids to provide evidence of the therapeutic efficacy of antisense oligonucleotides in X-linked Alport syndrome patients.

[NPJ Parkinson's Disease] Scientists examined human midbrain organoids derived from induced pluripotent stem cells carrying α-synuclein triplication and an isogenic control to assess early alterations in a 3D human model.

[EMBO Reports] Researchers demonstrated that both, acute mechanical manipulations as well as a persistent change in the mechanical environment provided to human brain organoids, instruct neural stem cell lineage decisions.

[Biomarker Research] The authors established patient-derived glioma organoids from 61 patients, including both IDH-mutant gliomas and IDH-wild type glioblastoma

[Lab on a Chip] Scientists presented a fully 3D-printed microfluidic platform for co-culture of hiPSC-derived retinal organoids containing intrinsic retinal pigment epithelium regions with endothelial cells.

[Life Sciences] The antigrowth effects of AdipoRon were observed in the patient-derived organoids PM154 and MSK-PCa16.

[Communications Biology] Investigators described a robust continuous feline intestinal organoid culture system without feeder cells to investigate whether the feline cellular and metabolic environment promotes sexual development of in vitro-generated merozoites.

[Protein & Cell] The authors explore how human tumor organoids serve as a transformative preclinical platform, bridging the gap between basic research and clinical translations.

[Stem Cell Research & Therapy] By combining the scalability of genome engineering with the physiological fidelity of organoids, CRISPR-integrated platforms are redefining the frontiers of experimental medicine.

[Investigational New Drugs] Scientists review the types of organoids, the application of patient-derived tumor organoids in developing new drugs, as well as their challenges and opportunities to provide powerful insights into drug development.