Neutrophil Extracellular Traps Induced by Tumor-Derived NGAL Reprogram CAF Subtypes via ITGA5 to Promote Tumor Progression in Pancreatic Cancer

Scientists delineated how neutrophil extracellular traps (NETs) instruct cancer-associated fibroblast subtype specification and immunosuppression in pancreatic ductal adenocarcinoma, identify upstream NETosis drivers and evaluate combinatorial therapeutic strategies targeting this axis.