Astrocytic mGluR5-Dependent Calcium Hyperactivity Promotes Amyloid-β Pathology and Cognitive Impairment

Scientists first quantified a high expression level of astrocytic mGluR5 in the hippocampus of Alzheimer’s disease brains and demonstrated that the expression of astrocytic mGluR5 was positively correlated with Alzheimer’s disease progression in both humans and mice.