Angiopoietin-TIE2 Feedforward Circuit Promotes PIK3CA-Driven Venous Malformations

In Pik3ca^H1047R-driven venous malformations mouse models, single-cell transcriptomics and lineage tracking revealed clonal expansion of mutant endothelial cells with a post-capillary venous phenotype, characterized by suppression of the AKT-inhibited FOXO1 and its target genes.