Regulation of Blood-Brain Barrier Integrity by Brain Microvascular Endothelial Cells in Ischemic Stroke: A Therapeutic Opportunity.

Scientists systematically discuss the central role of brain microvascular endothelial cells (BMECs) in ischemia. The mitochondrial dysfunction and activation of apoptosis/necrosis pathways in BMECs directly disrupt the integrity of the BBB and the degradation of junctional complexes further exacerbates its permeability.