NewslettersMammary Cell News SIRT5-Mediated Desuccinylation of MTHFD2 Enhances Chemoresistance in Breast Cancer Cells by Reducing Therapy-Induced Senescence By Emily Salmini - October 21, 2025 0 22 Researchers found that low activity or depletion of MTHFD2 enhanced the degree of tumor cell senescence in breast cancer cells and decreases their resistance to chemotherapeutic agents. [Communications Biology] AbstractGraphical Abstract