SIRT5-Mediated Desuccinylation of MTHFD2 Enhances Chemoresistance in Breast Cancer Cells by Reducing Therapy-Induced Senescence

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Researchers found that low activity or depletion of MTHFD2 enhanced the degree of tumor cell senescence in breast cancer cells and decreases their resistance to chemotherapeutic agents.
[Communications Biology]
AbstractGraphical Abstract