Newsletters

[Cell] The authors deciphered that sensory neurons, the dominant neuron type in the triple negative breast cancer ecosystem, drive the immune-excluded tumor microenvironment by stimulating a dense extracellular matrix.

[Advanced Materials] Scientists hypothesized that ECM softening in periodontal disease contributes to inflammation by dysregulating gingival fibroblasts.

[Nature Communications] Researchers showed that the ECM component hyaluronan mediates adherens junction-independent circulating tumor cell clustering in triple-negative breast cancers.

[Bone Research] Deletion of Foxi3 in the mouse cranial neural crest cells (CNCCs) did not disrupt mandible and auricular development, further confirming that FOXI3 does not directly regulate CNCCs.

[Current Biology] Investigators identified a novel calcium signaling axis involving the mechano-gated channel transient receptor potential vanilloid 4 (TRPV4), which regulates lamellipodial protrusions in various cell types.

[Biochimica Et Biophysica Acta-Molecular Cell Research] Scientists identified nuclear prelamin A recognition factor (NARF) as a novel matrix stiffness-responsive gene, whose transcription is directly regulated by the mechanosensor Yes-associated protein.

[Scientific Reports] The authors investigated the histopathological, biochemical, and molecular effects of topical esculin on full-thickness wounds in streptozotocin-induced diabetic rats.

[Scientific Reports] Researchers investigated the role of LIMK2, a component of the Rho/ROCK/LIMK/cofilin pathway, in cell differentiation and apoptosis in response to mechanical stimulation and proliferation in human dermal fibroblasts.

[FEBS Journal] Investigators provide an overview of the latest findings describing the roles of major bioactive fragments from collagens I, IV, VI, and XVIII in various physiological and pathological contexts affecting heart, lung, adipose, and even brain tissues.

[Apoptosis] The authors offer a systematic summary of the roles played by major cell adhesion molecules families—namely, the immunoglobulin superfamily, cadherins, and integrins—in the regulation of ferroptosis.

[FibroBiologics, Inc.] FibroBiologics, Inc. announced that the Canadian Intellectual Property Office has issued Canadian Patent No. 3118732, titled “Treatment of Cachexia Using Fibroblast Cells and Products Thereof.”

[Tissue Engineering and Regenerative Medicine] Researchers investigated endothelial cells from the stromal vascular fraction of human subcutaneous white adipose tissue in 2D culture and 3D bioengineered skin models to better define their specific subtypes.