Newsletters

[Journal of Nanobiotechnology] Scientists demonstrated that plant-derived exosome-like nanoparticles represent a novel and effective nanotherapeutic strategy for lymphedema by orchestrating metabolic reprogramming and inhibiting fibrosis.

[Journal of Translational Medicine] Investigators identified a Piezo1/Yes-associated protein 1 (YAP1)/glutaminase 1 (GLS1) axis linking mechanical stress to metabolic reprogramming and fibroblast activation in bladder outlet obstruction, which may serve as a therapeutic target to prevent fibrosis and preserve bladder function.

[American Journal of Respiratory Cell and Molecular Biology] Researchers showed that fibroblast growth factor 2 stimulated proliferation and expression of various fibrotic markers in human pulmonary fibroblasts from healthy donors and idiopathic pulmonary fibrosis patients.

[Scientific Reports] Researchers investigated cell adhesion molecule 1 (CADM1) function in connective tissue mast cells (CTMCs) using a monoclonal antibody against the extracellular domain of CADM1, termed 3E1.

[Scientific Reports] PCOS is characterized by hyperandrogenism and, here, scientists investigated the impact of androgens on fibrosis, cell-ECM interactions and mechanosensing. They reported an altered network of gene expression related to the genesis of fibrosis.

[Pediatric Research] Choline supplementation ameliorates the biochemical effects of bilirubin on L1 cell adhesion molecule in vivo on choline-deficient hyperbilirubinemic jj Gunn rat pups.

[Nature Reviews Immunology] The authors show how loss of stromal regulation through chronic inflammation, immune dysfunction, altered tissue biomechanics and metabolic stress can tip the balance from successful tissue repair to progressive fibrosis.

[PureTech Health (Businesswire)] PureTech Health announced that the US FDA and European Commission have granted Orphan Drug Designation to deupirfenidone for the treatment of idiopathic pulmonary fibrosis, a rare, progressive, and fatal lung disease.

[Hannover Medical School ] The Joachim Herz Foundation has selected the postdoc Carlos Hernandez Bautista, PhD student in the "Regenerative Sciences" PhD program at Hannover Medical School (MHH) and his project "Development of sustainable biomedicine for heart regeneration" for the "Add-on Fellowship for Interdisciplinary Life Science" and is supporting him with a grant of 15,000 euros.

[March of Dimes] March of Dimes announced leading hematologist and stem cell scientist Dr. Leonard Zon as the winner of the 2026 March of Dimes Richard B Johnston Jr, MD Prize for his work in developmental biology.

[Journal of the American Chemical Society] Researchers introduced a gelatin-based coacervate matrix with phase-transition-mediated tunable mechanics to recapitulate the biophysical cues of pre- and peri-implantation stages.

[Genes & Development] Scientists compared the dynamics of cytoplasmic versus chromatin-bound transcriptomes of naive and primed hESCs as well as fibroblasts. They found a remarkable enrichment for RNA transcribed from α-satellite repeat in the chromatin fraction of naive hESCs compared with primed hESCs.