Newsletters

[Lexicon Pharmaceuticals, Inc. ] Lexicon Pharmaceuticals, Inc. announced that randomization of patients has been completed in the pivotal Phase III clinical trial evaluating sotagliflozin in patients with non-obstructive and obstructive hypertrophic cardiomyopathy.

[Science] Investigators constructed a multimodal cell atlas of 36 human hearts spanning atrial and ventricular chambers, cataloging major cardiac cell types and their associated disease states.

[Circulation Research] Researchers revealed that heart failure with preserved ejection fraction (HFpEF) prompts cardiomyocytes to release small extracellular vesicles enriched with miR-200c-3p, leading to hypothalamic inflammation and evoking sympathetic outflow, which in turn exacerbates cardiac dysfunction.

[Cardiovascular Research] The authors established a direct mechanistic link between nuclear envelope dysfunction and impaired mitochondrial function, and highlight the mitochondrial calcium uniporter complex as a potential therapeutic target in LMNA-related cardiomyopathy.

[iScience] Investigators identified fibro/adipogenic progenitors (FAPs) as the primary source of CCL2 in acutely injured muscle, where the pro-inflammatory subcluster of FAPs expanded rapidly and expressed the highest level of CCL2.

[American Journal of Physiology-Lung Cellular and Molecular Physiology] Researchers hypothesized that, in human airway smooth muscle cells, carbonyl cyanide-p-trifluoromethoxyphenylhydrazone (FCCP)-induced mitochondrial depolarization activates the PINK1-Parkin-mediated mitophagy pathway, culminating in the clearance of damaged mitochondria.

[Scientific Reports] Researchers established a scaffold-free 3D spheroid model of murine and human aortic vascular smooth muscle cells derived from heart failure patients to mimic their multicellular organization, cell plasticity, and interactions with the extracellular matrix.

[Ageing Research Reviews] Scientists summarize current progress in single-cell technology with respect to skeletal muscle aging. They focused on specific molecular characteristics and interaction networks of muscle fiber, satellite, and immune cells during aging.

[Trends In Endocrinology and Metabolism] Using skeletal muscle and endurance exercise as a model system, scientists defined a local–systemic secretome axis shaped by spatial organization, stimulus-specific programs, temporal dynamics, extracellular processing, and paracrine circuitry.

[Humacyte, Inc.] Humacyte, Inc. announced that the FDA has accepted its Investigational New Drug application (IND) for a first-in-human clinical study of the coronary tissue engineered vessel (CTEV) in coronary artery bypass grafting. The CTEV is a universally implantable bioengineered human blood vessel.

[Cancer Discovery] Tracing the transcriptional response of liver metastasis–associated peritumoral and tumor endothelial cells (TEC) to T cell intervention, scientists discovered an immunomodulatory TEC subpopulation that highly expressed lipoprotein lipase (LPL).

[Science Advances] Investigators hypothesized that sphingosine-1-phosphate (S1P) reduces platelet adhesion and thrombus formation by up-regulation of endothelial thrombomodulin. This would identify S1P as an antithrombotic target without increasing bleeding risk.