Newsletters

[Science Advances] Researchers reported a thiol-rich immunomodulatory injectable hydrogel (TR-gel) that forms in situ through Michael addition between acrylated hyaluronic acid and thiolated hyaluronic acid. In a rat intrauterine adhesion model, TR-gel decreased collagen deposition, promoted angiogenesis, and improved the fertility rate from 25.0 to 62.5%.

[Damon Runyon Cancer Research Foundation] The Damon Runyon Cancer Research Foundation has named 14 new Damon Runyon Fellows, brilliant postdoctoral scientists conducting basic and translational cancer research in the laboratories of leading senior investigators.

[FibroBiologics, Inc.] FibroBiologics, Inc. announced that the United States Patent and Trademark Office has issued a patent that describes methods utilizing fibroblasts to improve the engraftment and long-term function of transplanted pancreatic islets, addressing one of the major challenges in islet transplantation.

[Acta Biomaterialia] To support human islet viability and function, researchers developed alginate-based bioinks incorporating human pancreatic decellularized ECM.

[Nature Biomedical Engineering] The authors define the hallmarks of fibrosis across organ systems to establish foundational design criteria necessary for modelling human fibrosis in vitro.

[Biomaterials] Scientists explored a localized biomaterial delivery strategy via regulating the crosslinking degree of hydrogel matrix, in which high-crosslinking density of hydrogel tends to exacerbate neuroinflammation via Piezo1 activation as well as Wwtr1-dependent macrophage reprogramming.

[Proceedings of the National Academy of Sciences of the United States of America] Investigators tracked and manipulated auditory cortical ECM integrity in Mongolian gerbils during perceptual learning. They found that the ECM undergoes rapid training-induced changes, degrading and returning to baseline within 24 hours of each session.

[Gut] Researchers combined single-cell RNA sequencing and spatial transcriptomics to comprehensively profile immune microenvironment changes in the remnant liver during associating liver partition and portal vein ligation for staged hepatectomy (ALPPS).

[Cancer Research] The authors demonstrated that elevated lactate levels in CAFs reprogram the epigenetic landscape to promote tumor progression and immunosuppression, highlighting the potential of targeting CAF histone lactylation as a therapeutic strategy for colorectal cancer.

[Journal of Dental Research] Scientists examine current mechanistic evidence undergirding myofibroblast activation, survival, and its phenotypic reversal, focusing on restoring glandular function.

[Nature Immunology] Researchers identified a population of immunomodulatory cancer-associated fibroblasts (CAFs) that play a pivotal role in shaping the lung tumor microenvironment by driving the recruitment of a highly immunosuppressive subset of CXCR3+ Treg cells.

[Nature Immunology] Scientists showed that TIF1γ-deficient Treg cells lose Foxp3 expression and acquire effector phenotypes in a cell-intrinsic manner upon inflammatory challenge.