Newsletters

[Biotechnology Advances] Successful macrophage immunotherapy requires solving two central in vivo determinants: preserving a therapeutically favorable functional state despite suppressive cues, and achieving robust, disease-selective localization and engagement.

[Blood] Investigators identified immunosenescence as a measurable and functionally consequential barrier to CAR T-cell efficacy in chronic lymphocytic leukemia and a candidate for therapeutic modulation.

[Leukemia] Researcher showed that CAR structure is a critical determinant of CD19 loss in tumor B cells. Specifically, repeated exposure to CD19–4-1BB-based CAR-T cells, but not CD19–CD28-based counterparts, drives FMC63-epitope and total CD19 protein loss.

[Nature Medicine] Scientists reported clinical and molecular data obtained during the nonrandomized Phase I part of the Phase I/II COMPARE trial, evaluating safety and efficacy of mivocabtagene autoleucel (miv-cel), an autologous fully human CD19 CAR T cell therapy, in rheumatoid arthritis.

[OHSU ] Dr. Trevor McGill at Oregon Health & Science University (OHSU) has received a major federal grant to develop a new generation of stem cell therapies that could one day help preserve sight for those with the disease without requiring long-term immune-suppressing drugs.

[Molecular Therapy] The authors identified tyrosine 218 (Y218) in the CD28 cytoplasmic domain as a critical regulatory site, and demonstrate that its phosphorylation is essential for optimal CAR-T cell activity.

[Cell Reports Medicine] Investigators evaluated the intrinsic and extrinsic effects of deleting the negative regulator Regnase-1 in B7-H3-CAR T cells for the immunotherapy of osteosarcoma.

[Cell] Researchers developed defined culture conditions that enable long-term expansion of mouse and human granulocyte-monocyte progenitors (GMPs) while preserving progenitor identity and myeloid potential, establishing GMPs as a renewable engineering platform.

[Nature Communications] Researchers revealed that early mitochondrial reprogramming, characterized by the activation of oxidative phosphorylation, is a determinant of differentiation initiation.

[Proceedings of the National Academy of Sciences of the United States of America] Scientists identified a previously unrecognized RNA-based mechanism that maintains pathogenic fibroblast states during skin fibrosis.

[Advanced Healthcare Materials] Investigators presented a 3D embedded bioprinting strategy for engineering vascularized biopatches through the precise integration of prevascularized multicellular spheroids within a skin-derived decellularized extracellular matrix bioink.

[Cell Death Discovery] Researchers showed that CaMK4 was highly expressed in CD4⁺ T cells from psoriatic lesional skin in both humans and mice.