Large-Scale Integration of Functional Assay Data for the Resolution of Germline BRCA1 and BRCA2 Variants of Uncertain Significance

Scientists collated and harmonized results from 185 individual instances of functional assays for 3,247 missense variants in BRCA1 and 147 individual instances of functional assays for 6,177 missense variants in BRCA2 to construct Functional Assay Integration databases.