Soluble N-Terminal EphA2 Fragment as a Diagnostic Biomarker and Functional Mediator of Tumor Progression in Triple-Negative Breast Cancer

Ephrin type-A receptor 2 (EphA2) undergoes membrane-type 1 matrix metalloproteinase (MMP14)-mediated cleavage that releases soluble N-terminal fragments. Researchers investigated the diagnostic and functional significance of this fragment in TNBC.