Customized Bioreactor Enables the Production of 3D Diaphragmatic Constructs Influencing Matrix Remodeling and Fibroblast Overgrowth

Researchers developed a tissue engineering approach based on decellularized diaphragmatic muscle and human cells for the in vitro generation of diaphragmatic-like tissues as a proof-of-concept of a new option for the surgical treatment of large diaphragm defects.