Targeting Tissue-Resident Memory CD8+ T Cells in the Kidney Is a Potential Therapeutic Strategy to Ameliorate Podocyte Injury and Glomerulosclerosis

Scientists found that renal tissue displayed high abundance of tissue-resident lymphocytes and the proportion of CD8+ tissue-resident memory T cells was significantly increased in the kidney from patients and mice with focal segmental glomerulosclerosis, diabetic kidney disease, and lupus nephritis.