Immune Regulation News

Immune Regulation News is an online resource covering research into the regulation, suppression, and modulation of the immune system.

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PLD1 and PLD2 Promote an Immunosuppressive Tumor Microenvironment via CCL19-Dependent Macrophage Polarization and PD-L1 Induction

June 5, 2026

[Experimental & Molecular Medicine] Researchers demonstrated that both genetic ablation and pharmacological inhibition of phospholipase D (PLD) 1 and PLD2 reprogram the tumor microenvironment and enhance antitumor immunity in a syngeneic melanoma model.

Rise Therapeutics Completes Enrollment in Four-Week Dose Expansion Cohort for the R-2487 Rheumatoid Arthritis Clinical Trial

June 5, 2026

[Rise Therapeutics] Rise Therapeutics announced the completion of full enrollment in the four-week dose expansion cohort of its Phase Ib clinical trial evaluating orally dosed R-2487 in patients with active rheumatoid arthritis. R-2487 is a synthetic biology-based immunotherapy designed to address underlying immune dysfunction in autoimmune diseases.

From Tregs to Tissue Remodelling: FOXP3 and IL-35 in the Inflammatory Landscape of Nasal Polyps

June 5, 2026

[Inflammation Research] The authors examine how Tregs release the potent immunosuppressive cytokine IL-35, suppressing effector T cell responses and encouraging Treg proliferation. Studies have shown that IL-35 is essential for preserving immunological homeostasis.

CCR2-Guided T Exosome-Gas6 Hybrid Synergistically Reprograms Macrophage Inflammation and Immune Tolerance in Gouty Arthritis

June 5, 2026

[Advanced Healthcare Materials] Investigators designed a bioresponsive therapeutic platform composed of Treg-derived exosomes co-loaded with growth arrest-specific protein 6 (Gas6), engineered to preferentially home to inflamed joints via CCR2-guided chemotactic targeting.

Intratumoral Regulatory T Cell Ablation Mediates Tumor Control Systemically Without Autoimmunity

June 5, 2026

[Cancer Research] Researchers used intratumoral (IT) delivery of diphtheria toxin (DT) in Foxp3DTR mice to deplete Tregs within tumor tissues while leaving peripheral Tregs intact. IT delivery of DT reduced Treg frequencies in the tumor, which promoted potent tumor control without autoimmunity.

Single-Cell Identifies and Validates Human Circulating Treg Subtype/State Tregfciin Non-Small Cell Lung Cancer

June 5, 2026

[Signal Transduction and Targeted Therapy] Using scRNA-seq and stereo-seq, scientists identified a novel circulating Treg subtype in non-small cell lung cancer. We developed a regional overlap-expression rate system with cell identity marker gene panels to quantify T cell subtype specificity across pre/post-operative blood, 31 diseases, and in 17 organs.

Annexin A1 and Its Membrane Receptor Complex: Implications for Immune Regulation and Autoimmune Disease Mechanisms

June 5, 2026

[Autoimmunity Reviews] Annexin A1 (AnxA1) acts as a molecular switch integrating receptor-mediated signals to fine-tune immune responses and mitigate tissue damage in chronic inflammatory and autoimmune diseases.

Early-Life Gut Microbiota and Allergic Diseases: Immune Regulatory Mechanisms and Intervention Progress

June 5, 2026

[Clinical Reviews in Allergy & Immunology] The gut microbiota plays a critical role in host metabolism, maintenance of mucosal barrier integrity, and regulation of immune homeostasis, and is especially closely linked to immune system development and the establishment of immune tolerance in early life.

PLA2G12A-Driven Extracellular Vesicle-Lipid Signaling Amplifies Pathogenic T Cell Responses in Inflammatory Diseases

June 5, 2026

[Cell Reports] Researchers showed that genetic deficiency or antibody-mediated neutralization of PLA2G12A, a secreted phospholipase A2 transiently upregulated in activated CD4+ T cells, prevents pathogenic Th17 differentiation and associated diseases including psoriasis and arthritis.

Tissue-Specific Tolerance Mechanisms and Lymph Node Co-Drainage Shape T Cell Immunity in the Upper Digestive System and Pancreatic Cancer Progression

June 5, 2026

[Cell Reports] High-dose hepatic-secreted ovalbumin (OVA) triggered antigen-specific T cell deletion, whereas secreted pancreatic and intestinal OVA induced Tregs cells, revealing immunological ignorance, clonal deletion, and Treg cell generation as tissue-specific tolerance mechanisms.

Keck Foundation Funds Three Innovative Early-Career Salk Projects

June 3, 2026

[The Salk Institute] Three Salk faculty members, Drs. Sung Han, Daniel Hollern, and Graham McVicker, have been chosen as Keck Scholars, alongside corresponding graduate students as Keck Fellows, in a special W. M. Keck Foundation Bridge Funding Initiative.

Ulcerative Colitis-Driven Gut Dysbiosis Exacerbates Periodontal Bone Loss through the Gut-Oral Axis /Th17/Treg Imbalance

June 3, 2026

[NPJ Biofilms and Microbiomes] Researchers found ulcerative colitis doubles alveolar bone loss, heightens systemic inflammation, oxidative stress, and osteoclastogenesis. Fecal microbiota transplantation (FMT) from DSS donors into antibiotic-pretreated periodontitis-prone mice replicated aggravated bone loss, systemic inflammation, gut-barrier leakage, and Th17/Treg imbalance, while healthy-donor FMT protected.

For over a decade, Immune Regulation News has been keeping the scientific community up-to-date with the latest research and reviews related to immune regulation. Key research areas covered include the roles of regulatory T cells (Treg cells) in autoimmunity and self-reactivity, as well as immune response to disease, transplantation and cancer. We also provide vital updates on the latest jobs and upcoming events in the field of immunology.