IFN-γ⁺ Cytotoxic CD4⁺ T Lymphocytes Are Involved in the Pathogenesis of Colitis Induced by IL-23 and the Food Colorant Red 40

Using single-cell transcriptomic analysis, scientists found that several CD4+ T-cell subsets were present in the intestines of colitic mice, including an interferon (IFN)-γ-producing subset.