Engineered Nanoerythrocyte Alleviate Central Nervous System Inflammation by Regulating the Polarization of Inflammatory Microglia

The authors developed an MG1 peptide and RVG29 peptide engineered nanoerythrocyte that could reprogram microglia from classical M1 toward alternative M2 by inducing heme oxygenase-1, stimulating Notch1/Hes1/Stat3 signaling, and further inhibiting NF-κB p65 translocation.