Ebola Virus VP35 Hijacks the PKA-CREB1 Pathway for Replication and Pathogenesis by AKIP1 Association

Researchers showed that Ebola virus VP35, a cofactor of viral RNA-dependent RNA polymerase, bound human A kinase interacting protein (AKIP1), which consequently activated protein kinase A (PKA) and the PKA-downstream transcription factor CREB1.